Police say they fear the worst for a woman who was reported missing in Brisbane late last month.

78-year-old Lesley Trotter was reported missing on March 28.

Her family raised the alarm after finding the door of her Toowong home unlocked with her keys and wallet still there.

After more than a week of searching to no avail, Detective Superintendent Andrew Massingham says there is only one possible outcome.

But with no confirmation of her body, the investigation continues with more than 40 detectives assigned to the case.

Bill McDonald relays the details and warnings from police.

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As the investigation continues, Detective Superintendent Andrew Massingham gave a media conference during Brisbane Live.

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If you have any information please contact police on 131 444.

Image: Queensland Police Service